|
KMID : 0043319940170060415
|
|
Archives of Pharmacal Research
1994 Volume.17 No. 6 p.415 ~ p.419
|
|
|
Studies of Complex Formation between the Bromophenol Blue and some Important Aminoquinoline Antimalarials
|
|
Saadia-Mohamed-El-Ashry
Aly Fatma-Ahmed
Amina-Mohamed-El-Brashy
|
|
|
Abstract
|
|
|
|
A simple nad rapid colorimetric method for the assay of amodiaquine hydrochloride, chloroquine phosphate and primaquine phosphate is described. The method is based on the interaction of the drug base with bromophenol blue to give a ion-pair complex. The spectra of the complex shows a maxima at 415-420 nm with high apparent molar absorptivities. Beer’s law was obeyed in the concentration range 1-8, 2-10 and for amodiaquine hydrochloride, primaquine phosphate and chloroquine phosphate respectively. The proposed method was applied to the determination of these drugs in certain formulations and the results were favourably comparable to the official methods.
|
|
|
KEYWORD
|
|
|
Bromophenol blue, Amodiaquine, Chloroquine, Primaquine, Colorimetry, Dosage forms
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|